Dr Chok and colleagues retrospectively studied the impact of postoperative complications on the long-term outcome of curative liver resection for hepatocellular carcinoma.
The team evaluated a total of 863 patients who had curative resection of hepatocellular carcinoma from 1989 to 2004.
The team reported that the median follow-up was 36 months.
The research team found that 33% of patients developed postoperative complications.
The hospital mortality rate was 5%.
The researchers found that multiple logistic regression analysis showed that older age and massive intraoperative blood loss were related to a significantly higher complication rate.
Demographics of patients with and without postoperative complications were comparable.
Patients with postoperative complications had significantly more blood loss, and required more transfused blood.
|The overall survival rate without complications at 1 year was 84%|
|British Journal of Surgery|
The overall survival rates of patients without complications at 1, 3, 5 and 10 years were 84%, 63%, 52% and 32% respectively.
The team observed that corresponding rates for those with complications were 68%, 52%, 42% and 27%, respectively.
Dr Chok’s team concluded, “Cox proportional hazard model analysis revealed that the presence of postoperative complications was independently associated with poor overall survival.“
“Postoperative complications can affect overall long-term survival after resection of hepatocellular carcinoma.”