The long-term sequelae of inflammatory bowel disease (IBD) may differ between children and adults.
Dr Pieta Turunen and colleagues from Finland evaluated the health status of patients with pediatric onset of inflammatory bowel disease and controls in early adulthood.
The team mailed a questionnaire on the current health status and disease history to patients with childhood onset inflammatory bowel disease diagnosed during 1987-2003 in 2 university hospitals in Finland.
Matched controls were randomly selected from the Population Register Centre.
The researchers reported that a total of 368 of the 550 patients, and 646 controls responded.
Ulcerative colitis was the most common primary diagnosis, reclassified as Crohn's disease in 9%.
Of the patients, 80% had been on glucocorticoids at some point.
The team found that 33% of Crohn's disease patients had undergone intestinal resection.
In ulcerative colitis, total colectomy was common, occurring in 24%.
|33% of Crohn's patients had undergone intestinal resection|
|Inflammatory Bowel Diseases |
The research team noted that the frequency of joint diseases and biliary duct diseases was higher in patients than in controls.
Overall quality of life was decreased in the patients.
Further, some impediment on adult height and weight was observed among male patients.
Dr Turunen’s team concluded, “Inflammatory bowel disease in children may have a more aggressive disease course than in adults, since most pediatric patients need glucocorticoids, and abdominal surgery is frequent.”
“At 8 years from diagnosis, most patients have active disease and quality of life is slightly lower than in the rest of the population.”