Metabolic syndrome comprises a cluster of metabolic abnormalities leading to insulin resistance and atherosclerosis, and Helicobacter pylori is thought to be a contributing factor.
Dr Toshiaki Gunji and colleagues from Japan examined the association between H pylori infection, and metabolic syndrome in a large Japanese population.
Consecutive asymptomatic subjects that underwent a complete medical survey between 2006 and 2007 were recruited.
The research team studied a total of 5488 men, and 1906 women were cross-sectionally.
The association of H pylori serostatus with traditional atherosclerosis risk factors was investigated by multiple linear regression analysis.
Independent and significant factors affecting metabolic syndrome were determined by multiple logistic regression analysis.
H pylori seropositivity significantly increased with age in both men and women.
|EM>H pylori seropositivity increased with age|
|The American Journal of Gastroenterology
The research team found that H pylori seropositivity was significantly higher in cases with metabolic syndrome compared with those without metabolic syndrome.
The team noted a significant and independent association between H pylori seropositivity and metabolic syndrome by multiple logistic regression analysis.
H pylori seropositivity was significantly associated with higher systolic blood pressure, lower high-density lipoprotein-cholesterol level, and higher LDL-cholesterol level by multiple linear regression analysis.
Dr Gunji’s team comments, “In a large Japanese population, H pylori infection was significantly associated with metabolic syndrome.”