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Fatigue in chronic Hep C is associated with patient and disease factors

The latest issue of the Journal of Hepatology examines the association between quality of life and fatigue with demographic factors, inflammatory activity, and degree of fibrosis in chronic Hep C.

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Health-related quality of life is impaired in patients with chronic Hepatitis C.

Dr Gerlinde Teuber and colleagues from Germany investigated health-related quality of life and fatigue in patients with chronic Hepatitis C virus infection in relation to the degree of fibrosis and inflammation.

The research team also controlled for the influence of relevant demographic and medical variables.

The team conducted a cross-sectional two-center study including 215 outpatients with chronic Hepatitis C applying the Short-Form Health Survey, and the Fatigue Impact Scale.

Absolute Fatigue Impact Scale score was increased with advanced fibrosis
Journal of Hepatology

The contribution to the variability of these psychometric scores was evaluated for the degree of fibrosis as well as viremia, gender, age, mode of transmission, genotype, and alanine transferase.

There was a strong negative association between the degree of liver fibrosis and the physical Short Form-36 summary score.

This was independent of the covariate age, also significantly predicting physical health-related quality of life.

The team noted that the absolute Fatigue Impact Scale score was significantly increased in patients with advanced fibrosis.

In females, the mental Short-Form-36 summary score, and fatigue were significantly more impaired.

Dr Teuber’s team concludes, “Our study suggests a significant association of physical aspects of health-related quality of life and fatigue with the extent of fibrosis.”

“Fibrosis stage should be considered for the identification and management of Hepatitis C patients at risk for reduced physical health-related quality of life.

 

J Hepatol 2008: 49(6): 923-9


18 November 2008

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