Studies exploring the association between appendectomy and Crohn's disease have reported conflicting findings.
Dr Gilaad Kaplan and colleagues from Canada conducted a systematic review of the literature and a meta-analysis to assess the risk of Crohn's disease following an appendectomy.
|Crohn's disease increased 1 to 4 years after an appendectomy|
|The American Journal of Gastroenterology |
The research team determined the effect of time between appendectomy and Crohn's disease diagnosis.
The team used MEDLINE to identify observational studies evaluating the association between appendectomy and Crohn's disease.
Authors were contacted when data were insufficient.
Relative risks with 95% confidence intervals were calculated using a random effects model.
Studies that analyzed their data by the interval between the appendectomy and the diagnosis of Crohn's disease were assessed separately.
The researchers observed the summary relative risks estimate for Crohn's disease following an appendectomy was significantly elevated, though heterogeneity.
The risk was elevated within the first year following the operation.
The team noted that the risk of Crohn's disease was also significantly increased 1 to 4 years following an appendectomy.
However, after 5 years or more, the risk fell to baseline levels.
Dr Kaplan’s team concluded, “The meta-analysis demonstrated a significant risk of Crohn's disease following an appendectomy, though heterogeneity was observed between the studies.”
“The elevated risk early after an appendectomy, which diminishes thereafter, likely reflects diagnostic problems in patients with incipient Crohn's disease.”