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Cardiovascular and cerebrovascular events in primary biliary cirrhosis

A population study in the latest issue of the American Journal of Gastroenterology examines the risk of cardiovascular and cerebrovascular events in primary biliary cirrhosis.

News image

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Hyperlipidemia is a common finding among patients with primary biliary cirrhosis.

Whether this results in higher rates of cardiovascular and cerebrovascular events in primary biliary cirrhosis patients compared with the general population is unclear.

Dr Masoud Solaymani-Dodaran and colleagues from the United Kingdom compared the risk of developing myocardial infarction, stroke and transient ischemic attack in a cohort of people with primary biliary cirrhosis with a general population control cohort matched on age, sex, and general practice.

Subjects were selected from the General Practice Research Database.

Hazard ratios and 95% confidence intervals were calculated using Cox regression.

Incidence rates per 1000 person-years for stroke was 14 for primary biliary cirrhosis
American Journal of Gastroenterology

The researchers compared 930 primary biliary cirrhosis patients with 9202 controls.

During a total of about 43,700 person-years of follow-up, 244 myocardial infarctions, 591 strokes, and 221 transient ischemic attacks were identified.

Incidence rates per 1000 person-years for myocardial infarction, stroke, and transient ischemic attack during the study period were 6, 14, and 5 for primary biliary cirrhosis cohorts.

Incidence rates per 1000 person-years for myocardial infarction, stroke, and transient ischemic attack during the study period were 6, 14, and 5 for control cohorts, respectively.

The team found hazard ratios in primary biliary cirrhosis cohort compared with the control cohort were 0.09 for any vascular event, 1.4 for myocardial infarction, 0.9 for stroke, and 0.7 for transient ischemic attack.

Adjustment for confounders did not change the results substantially.

Dr Solaymani-Dodaran and team concluded, “Primary biliary cirrhosis was not associated with an increased risk of myocardial infarction, stroke, or transient ischemic attack in this cohort.”

“Therefore, strategies for the prevention of vascular events in primary biliary cirrhosis patients should be similar to those in the general population.”

Am J Gastroenterol 2008: 103(11): 2784-88


07 November 2008

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