Reports on the impact of postoperative fever on survival after surgery in patients with colorectal cancer are contradictory.
Dr Jinn-Shiun Chen and colleagues from Taiwan examined possible associations between postoperative fever and long-term survival of patients who underwent resection of colorectal cancer.
The team investigated 2311 consecutive patients who underwent elective open colorectal resection for primary colorectal cancer at a single institution between 1995 and 1998.
The primary end points were cancer-specific and overall survival.
Multiple covariate impact of risk factors on survival rates was assessed by Cox regression analysis.
|Blood transfusion was a predictor of cancer-specific survival|
|Diseases of the Colon & Rectum |
The researcher found that a total of 12% of patients developed postoperative fever.
The most important independent risk factor for postoperative fever was postoperative morbidity.
Blood transfusion, Stage 4 disease, male gender, and rectal cancer were also independent risk factors for postoperative morbidity.
Cox regression modeling indicated that stage, histology, tumor location, and blood transfusion were statistically significant covariate predictors for cancer-specific survival.
Postoperative fever was not independently associated with cancer-specific or overall survival.
Dr Chen’s team concluded, “This study did not support the hypothesis that postoperative fever is an independent prognostic factor after colorectal resection for primary colorectal cancer.”