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News

A consortium in the USA investigates environmental and genetic factors of pancreatitis

A multicenter approach to recurrent acute and chronic pancreatitis in the United States is reported in the most recent issue of Pancreatology.

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Recurrent acute pancreatitis and chronic pancreatitis are complex syndromes associated with numerous etiologies, clinical variables and complications.

Dr David Whitcomb and colleagues from Pennsylvania, USA undertook the North American Pancreatitis Study 2 to understand the complex environmental, metabolic and genetic mechanisms underlying recurrent acute pancreatitis and chronic pancreatitis.

Between 2000 and 2006, a consortium of 20 expert academic and private sites prospectively ascertained 1000 human subjects with recurrent acute pancreatitis or chronic pancreatitis.

In addition, the team assessed 695 controls.

Standardized questionnaires were completed by both the physicians and study subjects, and blood was drawn for genomic DNA and biomarker studies.

All data were double-entered into a database and systematically reviewed to minimize errors and include missing data.

The consortium completed a prospective study of 1000 subjects
Pancreas

Data were organized according to diagnosis, supporting documentation, etiological classification, clinical signs and symptoms.

The team further organized data according to past medical history, family history, environmental exposures, medication use and therapeutic interventions.

Upon achieving the target enrollment, data were organized and classified to facilitate future analysis.

The research team described the approaches, rationale and datasets, along with final demographic results.

Dr Whitcomb‘s team commented, “The North American Pancreatitis Study 2 consortium has successfully completed a prospective ascertainment of 1000 subjects with recurrent acute pancreatitis and chronic pancreatitis from the USA.”

“These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie recurrent acute pancreatitis and chronic pancreatitis.”

Pancreatology 2008: 8(4): 520-31


21 October 2008

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