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 20 February 2018

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News

Hepatitis vaccination in Hep C patients

The latest issue of Alimentary Pharmacology & Therapeutics examines Hepatitis vaccination in patients with Hepatitis C at a large veterans administration medical center.

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Hepatitis vaccination is recommended in patients with chronic liver disease.

Dr Hachem and colleagues from Missouri, USA validated Current Procedural Terminology codes and drug codes for hepatitis vaccination in administrative databases.

The team calculated predictive values for hepatitis vaccination codes in a validation set of 168 patients.

Presence of Hep B vaccine codes yielded a positive predictive value of 98%
Alimentary Pharmacology & Therapeutics

The research team conducted a retrospective cohort study of 243 Hepatitis C virus-infected patients to determine rates of hepatitis vaccination and serological testing.

The research team determined vaccination rates in Hepatitis C virus-infected patients in a single large Veterans Administration Medical Center.

The researchers found that the presence of Current Procedural Terminology or drug codes for Hepatitis A vaccine yielded a positive predictive value and negative predictive value of 93% and 94%, respectively.

The presence of Hepatitis B vaccine codes yielded a positive predictive value of 98%, and a negative predictive value of 94%.

Among patients diagnosed with Hepatitis C virus between 2000 and 2005, receipt of hepatitis vaccination was documented in approximately 8% overall, and in 7% of patients with cirrhosis.

Half of the patients without hepatitis vaccinations were either not tested for immunity or had negative serology.

Dr Hachem’s team concluded, “Current Procedural Terminology or drug codes for hepatitis vaccinations in administrative data are highly predictive of the presence of vaccinations in medical records.”

“Our data suggest that there is significant under-utilization of vaccination in patients with Hepatitis C virus.”

Aliment Pharmacol Ther 2008: 28(9): 1078-87


15 October 2008

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