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 18 February 2018

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News

NSAID use increases the risk of GERD

A study in November’s issue of the Alimentary Pharmacology & Therapeutics finds that NSAID use is a risk factor for GERD.

News image

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Dr Philippe Ruszniewski and colleagues from France examined the relationship between non-steroidal anti-inflammatory use (NSAID) and gastro-esophageal reflux disease (GERD).

A self-administered questionnaire covering NSAID use and GERD symptoms (heartburn and acid regurgitation) was sent to a representative national sample of 10,000 French adults in 2005.

33% reported using NSAIDs during the previous 3 months
Alimentary Pharmacology & Therapeutics

Risk factors associated with GERD were identified by logistic regression analysis in respondents who were not taking aspirin or proton pump inhibitors.

A total of 7259 completed questionnaires were returned of which 6823 were evaluable.

Overall, 33% reported using NSAIDs during the previous 3 months.

The lifetime and 3-month prevalence rates of GERD symptoms were 37% and 21% respectively.

GERD symptoms were significantly more common among NSAID users than among non-users and a similar trend was seen for aspirin use.

The research team noted that proton pump inhibitors were received by 31% of respondents who reported experiencing GERD symptoms within the previous 3 months compared with 6% of those without symptoms.

However, only 20% of NSAID-treated respondents were receiving proton pump inhibitors.

The team found that NSAID use, age and female gender were independent predictors of GERD symptoms.

Dr Ruszniewski’s team comments, “ NSAID or aspirin use is a significant risk factor for GERD symptoms.”

Aliment Pharmacol Ther 2008: 28(9): 1134-9


14 October 2008

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