Dr Philippe Ruszniewski and colleagues from France examined the relationship between non-steroidal anti-inflammatory use (NSAID) and gastro-esophageal reflux disease (GERD).
A self-administered questionnaire covering NSAID use and GERD symptoms (heartburn and acid regurgitation) was sent to a representative national sample of 10,000 French adults in 2005.
|33% reported using NSAIDs during the previous 3 months|
|Alimentary Pharmacology & Therapeutics|
Risk factors associated with GERD were identified by logistic regression analysis in respondents who were not taking aspirin or proton pump inhibitors.
A total of 7259 completed questionnaires were returned of which 6823 were evaluable.
Overall, 33% reported using NSAIDs during the previous 3 months.
The lifetime and 3-month prevalence rates of GERD symptoms were 37% and 21% respectively.
GERD symptoms were significantly more common among NSAID users than among non-users and a similar trend was seen for aspirin use.
The research team noted that proton pump inhibitors were received by 31% of respondents who reported experiencing GERD symptoms within the previous 3 months compared with 6% of those without symptoms.
However, only 20% of NSAID-treated respondents were receiving proton pump inhibitors.
The team found that NSAID use, age and female gender were independent predictors of GERD symptoms.
Dr Ruszniewski’s team comments, “ NSAID or aspirin use is a significant risk factor for GERD symptoms.”