Little is known regarding the impact of hospital-acquired infection in acute pancreatitis.
Dr Bechien and colleagues from Massachusetts, USA conducted a population-based assessment of the impact of hospital-acquired infection on outcome in acute pancreatitis.
Patient data were obtained from the Cardinal Health Clinical Outcomes Research Database, a large population-based data set.
Cases with principal diagnosis by International Classification of Diseases between 2004 and 2005 were identified.
These cases were linked with recently reported hospital-acquired infection data collected by the Pennsylvania Health Care Cost Containment Council.
Identification of hospital-acquired infection was based on definitions set forth by the National Nosocomial Infection Surveillance System.
The researchers conducted a 5:1 multivariate propensity-matched cohort study to determine the independent contribution of hospital-acquired infection to in-hospital mortality, length of stay, and hospital charges.
|Overall mortality was 28% with hospital-acquired infection|
From 177 participating hospitals, there were 11,046 acute pancreatitis cases identified.
The team noted that less than 1% of patients developed an hospital-acquired infection.
Mortality in the overall acute pancreatitis population was 1% vs 11% among 405 matched non-hospital-acquired infection controls.
Overall mortality was 28% among patients who developed hospital-acquired infection.
The research team found that 15% of all deaths was associated with an hospital-acquired infection.
Both average length of stay and hospital charges were significantly increased among patients with hospital-acquired infection compared with matched non-hospital-acquired infection controls.
Dr Bechien’s team commented, “We determined that hospital-acquired infection had a major impact on mortality in acute pancreatitis.”
“Patients who developed hospital-acquired infection also had significantly increased length of stay and hospital charges.”
“These differences were not explained by increased disease severity alone.”
“Reducing hospital-acquired infection is an important step to improving outcome in acute pancreatitis.”