In this study, Drs Silvia Sookoian and Carlos J Pirola performed a systematic review to investigate the association between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness.
They included population- or hospital-based case-control studies investigating the relation between NAFLD and carotid intima-media thickness.
Literature searches identified 7 studies that met the inclusion criteria.
|Carotid plaques were more frequently observed in NAFLD patients.|
|Journal of Hepatology|
The studies included a total of 1427 patients and 2070 controls.
Drs Sookoian and Pirola found a significant association between NAFLD and carotid intima-media thickness in both fixed and random models.
Meta-regression analysis showed that mean differences in alanine aminotransferase and g-GT were strongly correlated with intima-media thickness.
The team also found that carotid plaques were more frequently observed in NAFLD patients compared with controls.
Drs Sookoian and Pirola concluded, "Routine measurement of carotid intima-media thickness might be implemented in NAFLD patients, as they carry an increase of 13%."