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 19 February 2018

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News

H pylori 'test and treat' vs acid suppression for managing dyspepsia

The latest Alimentary Pharmacology & Therapeutics compares H pylori 'test and treat' with empirical acid suppression for managing dyspepsia.

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Whether Helicobacter pylori 'test and treat' or empirical acid suppression is preferred for the initial management of uncomplicated dyspepsia is controversial.

Dr Ford and colleagues from Canada conducted a meta-analysis of randomized controlled trials of 'test and treat' vs empirical acid suppression in adults with uncomplicated dyspepsia in primary care.

The weighted mean difference in costs was -£28.91
Alimentary Pharmacology & Therapeutics

The team evaluated original data sets for analysis.

The team examined effect of management strategy on symptom status and dyspepsia-related resource use at 12-month follow-up by pooling symptom and cost data.

The researchers obtained the relative risk of remaining symptomatic at 12 months and weighted mean difference in costs between the 2 strategies with 95% confidence intervals.

The researchers identified 3 eligible randomized controlled trials containing 1547 patients, of whom 791 were assigned to 'test and treat'.

There was no difference detected in symptom-cure at 12 months.

There was a nonsignificant trend towards cost-savings with 'test and treat'.

The weighted mean difference in costs was -£28.91.

Dr Ford's team concluded, "There was little difference in symptom-resolution or costs between the 2 strategies."

"A combination of patient and physician preference should determine the initial approach to the management of uncomplicated dyspepsia."

Aliment Pharmacol Ther 2008: 28(5): 534-44
12 August 2008

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