Dr Rita Raafat Gad and colleagues from Egypt determined predictive factors associated with a sustained virological response with combined interferon therapy among Egyptian patients infected by genotype 4 Hepatitis C virus.
|Sustained virological response was achieved in 55% of patients|
The team analyzed individual data from 250 patients with genotype 4 chronic Hepatitis C, treated with different regimens of combined interferon.
The primary end point was virological response defined as undetectable Hepatitis C virus RNA by polymerase chain reaction 24 weeks after the end of treatment.
Multivariate logistic regression analysis was performed to select the independent prognostic parameters associated with virological response.
The researchers achieved a sustained virological response among 55% patients.
Baseline factors independently and negatively associated with virological response were serum a-fetoprotein level, and severe fibrosis.
Presence of steatosis, and standard interferon treatment were also independently and negatively associated with virological response.
Dr Gad's team concluded, "Among genotype 4 chronic Hepatitis C patients, severe fibrosis, severe steatosis, treatment with standard interferon and a high serum a-fetoprotein level were all negatively associated with virological response."
"Pretreatment serum alfa-fetoprotein level should be considered in the routine assessment of factors predictive of a treatment response."