Relationships between pain threshold during rectal distension and both symptoms intensity and alteration in quality of life in irritable bowel syndrome (IBS) patients have been poorly evaluated.
|66% of patients had rectal hypersensitivity|
|Alimentary Pharmacology & Therapeutics|
Dr Sabate and colleagues from France evaluated relationships between rectal sensitivity, irritable bowel syndrome symptom intensity, and quality of life in a multicenter prospective study.
The team measured rectal threshold for moderate pain during rectal distension in irritable bowel syndrome patients.
The research team assessed irritable bowel syndrome symptoms intensity by a validated questionnaire.
Quality of life was measured by the Functional Digestive Disorder Quality of Life questionnaire.
The researchers evaluated 68 patients.
The mean rectal distending volume for moderate pain was 127 mL.
The team noted that 66% of patients had rectal hypersensitivity.
The team found rectal threshold was not significantly related either to overall irritable bowel syndrome intensity score, or to functional Digestive Disorder Quality of Life score.
Among functional Digestive Disorder Quality of Life domains, only anxiety and coping were significantly related with pain threshold.
Dr Sabate's team concluded, "In this study, most irritable bowel syndrome patients exhibited rectal hypersensitivity."
"No significant correlation was found between rectal threshold and either symptom intensity or alteration in quality of life."