Dr Manfredi and colleagues from France initiated mass screening for colorectal cancer in pilot regions on the basis of the fecal occult blood test followed by colonoscopy in positive cases.
The team reported on the colonoscopy results in one of the first areas to be screened.
|Colorectal cancer was diagnosed in 11%|
The team noted that the total regional population was 908,449.
The researchers reported that 187,342 of the 213,635 potential screening candidates who were aged 50 to 74 years were invited for fecal occult blood test.
Of the 51% compliant individuals, 3% were positive, and of these 91% agreed to undergo colonoscopy.
The colonoscopy procedure details, findings, and complications were recorded in 2246 patients.
Subjects were classified according to the most advanced lesion.
The team calculated positive predictive values of fecal occult blood test according to sex and age.
The researchers found colonoscopy was complete in 96% of cases.
Adverse events were encountered in less than 1%.
The research team found that colorectal cancer was diagnosed in 11%, 78% of which were clinical stages 1 to 2.
The rates of overall adenomas and advanced adenomas were 33% and 22%, respectively.
The team observed that the risk of cancer and advanced adenoma increased significantly in men and in older people.
Dr Manfredi's team concluded, "The results of mass screening with fecal occult blood test followed by colonoscopy in this population-based study are very encouraging in terms of compliance, early findings, and complications."
"Extension of this program to the whole of France is justified."