People at risk for coronary heart disease are often at risk for nonalcoholic fatty liver disease.
The association of modest wine consumption with nonalcoholic fatty liver disease has not been studied.
The recommendation of wine for patients at risk for both diseases is controversial.
|NAFLD was suspected in 3% of nondrinkers vs 0.4% of modest wine drinkers|
Dr Jeffrey Schwimmer and colleagues from California, USA investigated whether modest wine consumption is associated with decreased prevalence of nonalcoholic fatty liver disease.
The team evaluated participants from the Third National Health and Nutrition Examination Survey.
The participants reported either no alcohol consumption or preferentially drinking wine with a total alcohol consumption up to 10 g per day.
Suspected nonalcoholic fatty liver disease was based on unexplained serum alanine aminotransferase elevation over the cut point of the reference laboratory, and the cut point based on the 95th percentile of healthy subjects.
Multivariate analysis was adjusted for age, gender, race, neighborhood, income, education, caffeine intake, and physical activity.
A total of 7,211 nondrinkers, and 945 modest wine drinkers comprised the study sample.
Based on the reference laboratory cut point, the team identified suspected nonalcoholic fatty liver disease in 3% of nondrinkers and 0.4% of modest wine drinkers.
The adjusted odds ratio was 0.15 using the reference laboratory cut point.
The team identified suspected nonalcoholic fatty liver disease in 14% of nondrinkers, and 9% of wine drinkers using the healthy subject cut point.
The adjusted odds ratio was 0.5 based on the healthy subject cut point.
Dr Schwimmer's team concluded, "Modest wine consumption is associated with reduced prevalence of suspected nonalcoholic fatty liver disease."
"The current study supports the safety of one glass of wine per day for cardioprotection in patients at risk for both coronary heart disease and nonalcoholic fatty liver disease."