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 25 February 2018

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News

Response to biological therapies for active luminal Crohn's is varied

The latest Alimentary Pharmacology & Therapeutics undertook a meta-analysis of remission and response of biological therapies for active luminal Crohn's.

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Remission and response are the main outcomes to evaluate the efficacy of new treatments for Crohn's disease.

Dr Cottone and colleagues from Italy explained variation of remission and response rates in active luminal Crohn's disease.

The team studied control patients from trials of biological therapies through articles retrieved by MEDLINE search between 1997 to 2007 and by bibliography review.

The research team identified 1,913 control patients from 28 trials.

The pooled control rate of response was 33%
Alimentary Pharmacology & Therapeutics

There were 3 independent observers who extracted data.

Data were pooled by DerSimonian and Laird random effect model.

Factors influencing remission and clinical response were explored by metaregression for aggregated data.

The researchers found that the pooled control rates of remission and response were 17% and 33%, respectively, both with significant heterogeneity among studies.

At metaregression, the time of primary outcome evaluation was associated with remission.

However, the trial's criteria for defining response and publication year were predictors of response.

CDAI score, CRP levels or other clinical variables related with disease activity or concomitant medications were not significant factors.

Dr Cottone's team commented, "Populations used as ‘add-on' treatment comparator in trials of biological therapies for active luminal Crohn's disease are poorly characterized and outcomes are heterogeneous."

"Planning of future trials will require better description of patients and concomitant therapies, blinding of outcome assessors and homogeneous criteria of outcome definition."

Aliment Pharmacol Ther 2008: 27(12): 1210-23
27 May 2008

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