Advanced donor age is a risk factor for poor outcome in liver transplantation.
Dr Matteo Cescon and colleagues from Italy reviewed 553 consecutive transplants according to donor age categories.
There were 173 patients in Group 1 who were under the age of 50 years, and 96 in Group 2 between the ages of 50 to 59 years.
Group 3 included 132 patients between 60 and 69 years of age, Group 4 included 111 patients between 70 and 79 years, while Group 5 had 41 patients aged 80 years.
|5-year graft survival was higher in Group 1 at 75%|
Clinical parameters were comparable between groups.
The team found Group 5 had the highest proportion of pretransplant liver biopsy, at 85%.
There was only 1 graft in Group 5 that showed macrovesicular steatosis of more than 30%, and the lowest ischemia time.
The team noted that 5-year graft survival was significantly higher in Group 1 at 75% vs 60% in Groups 3, and 62% in Group 4.
The 5-year graft survival was 81% in Group 5.
The researchers noted that donor age of 60 to 79 years, and recipient Hepatitis C virus-positive status predicted poor survival.
Model for End-Stage Liver Disease score 25, and emergency liver transplantation were also predictors of poor survival.
In Hepatitis C virus-positive patients, 5-year graft survival was 72% in Group 1, 85% in Group 2, 52% in Group 3, 65% in Group 4, and 71% in Group 5.
Dr Cescon's team concluded, "Older donor grafts managed with routine graft biopsy and short ischemia time may work effectively, regardless of the severity of the recipient's liver disease."