Little is known about the descriptive epidemiology of colorectal adenomas diagnosed in the population.
Dr Cottet and team from France described time trends in the rate of first diagnosis of colorectal adenomas and estimated the proportion of adenoma-bearing individuals detected over a 24-year period.
|For advanced adenomas, the diagnosis increased by 7% for men|
|Alimentary Pharmacology & Therapeutics|
The team first-diagnosed a total of 11,027 patients with colorectal adenomas among Côte-d'Or residents in France between 1976 and 1999.
The team estimated annual percentage changes using a Poisson regression model.
The proportion of diagnosed adenoma-bearing individuals was estimated using the prevalence of adenomas in an autopsy study performed in the area.
The researchers found standardized diagnosis rates were 90 per 100,000 for men, and 50 per 100,000 women.
During the period 1976 to 1993, diagnosis rates significantly increased with annual percentage changes in men and women of 17% and 22%, respectively, for proximal adenomas.
The team found that diagnosis of distal adenomas increased by 8% and 9% for men and women, respectively.
For advanced adenomas, the diagnosis increased by 7% and 8% for men and women, respectively.
The research team noted that changes were less marked during the period 1994 to 1999.
The estimated proportion of adenoma-bearing individuals diagnosed during the 24-year period was 20% in men, and 16% in women.
Dr Cottet's team concluded, "Despite a marked increase in the rate of first adenoma diagnosis, the proportion of diagnosed adenoma-bearing individuals seems too low to induce a significant decrease in colorectal cancer incidence."