The relationship between stages of chronic Hepatitis B liver disease and health-related quality of life is an important aspect of the overall management of Hepatitis B virus infection, yet is not well characterized.
Dr Siew Chin Ong and colleagues from Singapore examined health-related quality of life in Hepatitis B virus patients, stratified by disease severity, compared with normal controls and hypertensive patients.
|The physical component deteriorates only with advanced liver disease|
The team used the Short Form 36 Health Survey and the EQ-5D self-report questionnaire.
Univariate and multivariate analyses were then performed.
The team assessed a total of 432 Hepatitis B virus.
Of these, 156 were asymptomatic carriers, 142 had chronic Hepatitis B, and 66 had compensated cirrhosis.
A further 24 had decompensated cirrhosis, and 22 had hepatocellular carcinoma.
The team reported that 22 were post-liver transplant patients, 93 were hypertensive patients, and 108 normal controls participated in the study.
The team showed that normal controls and asymptomatic carriers had similar Short Form 36 Health Survey scores, which were better than those for hypertensive patients.
However, those with chronic Hepatitis B and compensated cirrhosis showed a significant decrease in general health and the mental dimension.
The researchers observed that patients with advanced liver disease had significantly lower scores in all components.
This indicates that the physical component deteriorates only with advanced liver disease.
The team found similar results with the EQ-5D self-report questionnaire.
Post-liver transplant patients had similar health-related quality of life to patients with decompensated cirrhosis and hepatocellular carcinoma, although there was a trend toward improvement.
Dr Ong's team concluded, "Our results showed that health-related quality of life in asymptomatic carriers is comparable to those of normal controls and better than hypertensive patients."
"However, this deteriorates with disease progression, initially in general health and mental dimensions, but with advanced disease all dimensions are affected."