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 26 May 2018

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News

Liver gene expression predicts response to Hep C treatment

Liver gene expression predicts response to pegylated interferon plus ribavirin combination therapy in patients with Hepatitis C, finds this month's Gut.

News image

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The gold standard treatment of chronic Hepatitis C is combined pegylated interferon and ribavirin considering side effects and treatment cost, prediction of treatment response before therapy is important.

73% were predicted as sustained virological responders with the 2-gene classifier
Gut

Dr Asselah and colleagues from France identified a liver gene signature to predict sustained virological response in patients with chronic Hepatitis C.

The team assessed patients separated into 2 Groups.

Group 1 comprised 40 patients with chronic Hepatitis C including 14 non-responders, and 26 sustained virological responders.

Group 2 included 29 patients including 9 non-responders, and 20 sustained virological responders.

The researchers included 11 responder-relapsers.

The team selected a total of 58 genes associated with liver gene expression dysregulation during chronic Hepatitis C from the literature.

The team used real-time quantitative polymerase chain reaction assays to analyse the mRNA expression of these 58 selected genes in liver biopsy specimens taken from the patients before treatment.

In Group 1, the team identified 3 genes whose expression was significantly increased in non-responders compared with sustained virological responders, including IFI-6-16/G1P3, IFI27 and ISG15/G1P2.

These 3 genes also showed significant differences in their expression profiles between non-responders, and sustained virological responders in Group 2.

The team found supervised class prediction analysis identified a 2-gene signature, including IFI27 and CXCL9.

This accurately predicted treatment response in 79% of patients from Group 2.

The predictive accuracy was 100% in non-responders, and 70% in sustained virological responders.

The expression profiles of responder-relapsers did not differ from those of non-responders and sustained virological responders.

The researchers observed that 73% of patients were predicted as sustained virological responders with the 2-gene classifier.

Dr Asselah's team concluded, "Non-responders and sustained virological responders have different liver gene expression profiles before treatment."

"The most notable changes occurred mainly in interferon-stimulated genes."

"Treatment response could be predicted with a 2-gene signature."

Gut 2008: 57(4): 516-24
18 March 2008

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