Gallstone disease and cardiovascular disease are common diseases worldwide with considerable economical impact and they are strongly associated.
Carotid atherosclerosis is an excellent marker of risk for cardiovascular disease like stroke and myocardial infarction.
|Subjects with gallstone disease exhibited a higher carotid artery intima-media thickness|
Dr Nahum Méndez-Sanchez and colleagues from Mexico assessed the association between gallstones and carotid atherosclerosis.
The team conducted a cross-sectional study.
The team evaluated subjects with ultrasonographical evidence of Gallstone disease, and asymptomatic subjects without such evidence.
Anthropometric, clinical and biochemical variables were collected.The Metabolic syndrome was evaluated using adult treatment panel III criteria.
The research team determined carotid artery intima-media thickness by a standard ultrasound protocol.
Insulin-like growth factor-1 serum levels were measured in all subjects.
The researchers studied 191 subjects, of which 62 subjects had gallstone disease, and 129 were asymptomatic subjects without gallstone disease.
Subjects with gallstone disease exhibited a higher body mass index, body fat percent, insulin serum levels and carotid artery intima-media thickness.
The team found the prevalence of gallstone disease was higher in subjects with a carotid artery intima-media thickness over 0.75 independently of other factors.
For every 0.1 mm increase in carotid artery intima-media thickness the independent probability to be a case of gallstone disease increased by a factor of 1.25.
The researchers observed that insulin-like growth factor-1 levels did not differ among groups.
Dr Méndez-Sanchez's team concluded, "Subjects with gallstone disease exhibit greater carotid atherosclerosis, and therefore have a higher risk for stroke and myocardial infarction."