Little is known about risk factors for acute pancreatitis other than gallstones and alcohol consumption.
Dr Björn Lindkvist and colleagues from Sweden investigated whether smoking or body mass index are associated with acute pancreatitis.
The researchers determined relative risks for acute pancreatitis related to smoking, body mass index, and alcohol consumption.
|Smoking was associated with a relative risk of 3.6 for acute pancreatitis|
From 1974 to 1992, selected birth-year cohorts of residents in Malmö, Sweden were invited to a health-screening investigation including physical examination, blood sampling and a questionnaire.
The team assessed a total of 33,346 individuals.
The researchers identified 179 cases of acute pancreatitis from diagnosis registries.
The team calculated incidence rates in different risk factor categories, and used Cox's analysis to reveal relative risk.
The researchers found current versus never smoking at baseline was associated with acute pancreatitis, after adjustment for age, sex, body mass index, and alcohol consumption.
The team found that this association was stronger in heavy smokers.
Smoking was associated with a relative risk of 3.6 for acute pancreatitis in subjects who reported no alcohol consumption.
An increased risk for acute pancreatitis was also found for self-reported alcohol consumption.
The researchers observed a weak correlation between body mass index, and acute pancreatitis.
Dr Lindkvist's team concluded, "Smoking is associated with the incidence of acute pancreatitis in a dose-response manner."