Crohn's disease can commonly involve the terminal ileum, which is the site of B12 absorption.
Dr Peggy Headstrom and colleagues from the USA defined the prevalence of vitamin B12 abnormalities in a population with Crohn's disease.
The research team identified risk factors associated with B12 abnormalities in Crohn's disease.
|18% of patients with Crohn's had an abnormal serum B12 concentration|
|Inflammatory Bowel Diseases|
The team retrospectively reviewed the medical records of 201 patients with Crohn's disease at a tertiary care center.
The prevalence of B12 deficiency in a control population of 40 patients with ulcerative colitis was also assessed.
The researchers found that the prevalence of an abnormal serum B12 concentration in patients with Crohn's disease was 18% compared with 5% in ulcerative colitis controls.
The team found risk factors for B12 deficiency in patients with Crohn's disease included prior ileal or ileocolonic resection, and the need for ongoing medical therapy.
The team found neither disease location nor duration was independently associated with the risk of B12 deficiency.
Dr Headstrom's team concluded, "Vitamin B12 abnormalities are common in patients with and patients with a prior ileal or ileocolonic resection are at particular risk."
"Routine screening for B12 deficiency in patients with Crohn's disease is warranted."