Ischemic colitis has been associated with a number of diverse disorders and risk factors, including irritable bowel syndrome and constipation.
Professor Lin Chang and colleagues from California, USA conducted a large-scale population study, and assessed the potential risk factors associated with ischemic colitis.
|19 independent variables were associated with increased risk for ischemic colitis|
|Neurogastroenterology & Motility|
The team identified patients with ischaemic colitis and matched controls without ischaemic colitis using the medical and pharmacy claims data from the HealthCore Managed Care Database from 2000 to 2005.
The team developed a multivariate conditional logistic regression model to identify significant risk factors of ischemic colitis.
Interactions of age, sex, prior irritable bowel syndrome diagnosis, and prior constipation diagnosis were also evaluated.
The researchers identified 1754 patients with ischemic colitis and 6970 non-ischemic colitis controls.
Of these, 64% were women, and mean ages were 63 years.
The team found that the final parsimonious model comprised 19 independent variables associated with increased risk for ischemic colitis.
These included shock, dysentery, bloating, irritable bowel syndrome, colon carcinoma, constipation, cardiovascular disease, and dyspepsia.
Abdominal, aortic, or cardiovascular surgery, 12-month laxative, H2 receptor blocker and oral contraceptive use were also associated with ischemic risk.
The team observed a significant interaction between age and prior irritable bowel syndrome on risk for ischemic colitis.
Professor Chang's team concluded, "Multiple risk factors for ischemic colitis were identified, and the team confirmed that patients with irritable bowel syndrome or constipation are at greater risk for ischemic colitis.