Dr Jonas Ludvigsson and colleagues from Sweden examined the risk of pancreatitis in patients with celiac disease from a general population cohort.
The team accessed the Swedish national registers, and identified 14,239 individuals with a diagnosis of celiac disease between 1964 to 2003.
The team also assessed 69,381 reference individuals matched for age, sex, calendar year, and county of residence at the time of diagnosis.
|There were 95 positive events in individuals with celiac disease|
|Clinical Gastroenterology and Hepatology|
The team used Cox regression to estimate the hazard ratios for a subsequent diagnosis of pancreatitis.
The team restricted analyses to individuals with more than 1 year of follow-up, and no diagnosis of pancreatitis before or within 1 year after study entry.
Conditional logistic regression estimated the association of pancreatitis with subsequent celiac disease.
The researchers found that celiac disease was associated with an increased risk of subsequent pancreatitis of any type.
The team observed 95 positive events in individuals with celiac disease vs 163 positive events in reference individuals, and chronic pancreatitis.
Adjustment for socioeconomic index, diabetes mellitus, alcohol-related disorders, or gallstone disease had no notable effect on the risk estimates.
The team found that the risk increase for pancreatitis only among individuals with celiac disease diagnosed in adulthood.
Pancreatitis of any type, and chronic pancreatitis were associated with subsequent celiac disease.
Dr Ludvigsson's team concluded," This study suggests that individuals with celiac disease are at increased risk of pancreatitis."