The clinical significance of the trophic effects of long-term proton pump inhibitors (PPIs)-related hypergastrinemia on colon polyps remains unknown.
Dr Triadafilopoulos and colleagues from California, USA studied the frequency, growth, and histology of colon polyps in patients on chronic proton pump inhibitors therapy, compared to those not receiving acid suppression.
|PPIs use is associated with a reduction in hyperplastic polyps|
|Alimentary Pharmacology & Therapeutics|
The team reviewed medical records of 2868 consecutive patients who underwent 2 or more colonoscopies, performed 3 or more months apart.
The researchers compared 116 cases that used proton pump inhibitors between the 2 colonoscopies to 194 controls.
The researchers found that demographics and risk factors for colon cancer were comparable between the 2 groups.
The team noted that at baseline, the mean frequency and size of adenomatous polyps were similar in cases and controls.
At follow-up, the mean frequencies for each group were 0.9 and 1.2, and the sizes were 4.09 mm and 4.00 mm, respectively, with no significant change.
However, the control group had a higher mean frequency and size of hyperplastic polyps at baseline as well as at follow-up colonoscopy.
Dr Triadafilopoulos' team concluded, "The long-term use of proton pump inhibitors does not influence the frequency, growth, or histology of adenomatous polyps."
"However, it is associated with a reduction in both baseline and interval development of hyperplastic polyps."