Pyogenic liver abscesses are infrequent but potentially life threatening.
Factors related to mortality have been less studied.
Dr Ruiz-Hernandez and colleagues reviewed 84 patients, of which 56 were men and 28 were women, with a mean age of 64 years.
The patients were hospitalized between 1992 and 2005 owing to a pyogenic liver abscess .
|The mortality rate was 19%|
|European Journal of Gastroenterology & Hepatology|
The past medical history, clinical signs and symptoms, laboratory values, imaging studies, microbiological features, treatment, complications and mortality were recorded.
Factors related to complications and mortality were analyzed.
The researchers isolated 1 or more bacteria in 77% of patients.
The team identified Streptococcus spp. in 41%, Escherichia coli in 27%, Klebsiella spp. in 14%, and anaerobics in 18% of patients.
The team found complications developed in 61% of the cases, the most common one being a right pleural effusion in 35% of patients.
The mortality rate was 19%.
The team found mortality was associated with age, a previous history of coronary heart disease, absence of fever.
Development of sepsis and/or septic shock, and a raise of bilirubin levels were also associated with mortality.
The team noted that a biliary or cryptogenetic origin, and infection owing to E. coli. or to Candida were associated with mortality.
In addition, the researchers observed that mortality was associated with the development of pneumonia.
Logistic regression revealed sepsis and/or septic shock as an independent risk factor for mortality.
Dr Ruiz-Hernandez's team concluded , "Mortality associated with pyogenic liver abscess is high."
"The main risk factor for mortality is the development of sepsis and/or septic shock."