Donor safety has been scrutinized by both the medical community and the media.
Variability exists in reported donor complications, and associated risk factors are ill defined.
Dr Peter Abt and colleagues from Philadelphia, USA used administrative data to overcome the bias of single-center studies, and explored variables associated with untoward events.
The research team conducted a retrospective cohort study identifying living liver donors in 2 large healthcare registries.
The team identified 433 right and left lobe donors from 13 centers between 2001 and 2005.
|The overall complication rate was 29%|
|American Journal of Transplantation|
Perioperative complications were identified using International Classification of Diseases, 9th Revision coding data.
The team classified classified perioperative complications according to the Clavien system.
The team applied logistic regression models to determine factors associated with complications.
There was 1 perioperative death.
The overall complication rate was 29%, and major complication rate defined by a Clavien grade of 3 was 4%.
The research team found that center living-donor volume was associated with a lower risk of all complications.
The ratio of living-donors to all donors was also associated with a lower risk of all complications.
The team observed that donor age over 50 years was associated with a higher risk of major complications.
Dr Abt's team concluded," Living liver donation is currently performed with a low risk of major morbidity."
"Use of administrative data represents an important tool to facilitate a better understanding of donor risk factors."