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 24 May 2018

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News

Comparison of cost-effectiveness of anti-Hep B therapies

The latest Journal of Gastroenterology and Hepatology compares cost-effectiveness of antiviral therapies in Hepatitis B.

News image

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Economic efficiency of the alternative antiviral therapies for chronic Hepatitis B has not been systematically investigated and their quality remains unknown.

Professor You-Ping Ling and colleagues from China systematically reviewed economic evidence of antiviral therapies for chronic Hepatitis B.

The team searched 6 databases and 8 major journals supplemented with screening references of eligible studies.

Adefovir salvage produced $8446 per quality-adjusted life years
Journal of Gastroenterology and Hepatology

Full economic evaluations comparing alternative antiviral therapies in patients with chronic Hepatitis B virus infection were included.

The team reported that 2 investigators assessed the study quality and transferability, independently.

Data were analyzed qualitatively with adjustment when appropriate.

The researchers included 14 studies.

The team found that quality was high in 5 studies, moderate in 1 US and 5 Chinese studies, and low in 3 Chinese studies.

The major problems of quality are costing methods and analysis and the presentation of results.

The team found that in Australia and Poland, lamivudine-preferred strategies dominated interferon-alpha from the health-care sector perspective.

In the US, adefovir salvage produced US $8446 per additional quality-adjusted life years compared with interferon-alpha.

In Spain, the researchers observed that the cost of adefovir was US $34,840 for additional virological response.

In Taiwan, the use of pegylated interferon-alpha produced US $11,711 per additional quality-adjusted life years, compared with lamivudine.

In China, the incremental cost-effectiveness ratios of combination therapy lamivudine ranged from US $2860 to US $22,160 per additional loss of Hepatitis B e antigen.

The team noted that interferon-alpha versus lamivudine ranged from US $2490 to US $8890 per additional loss of Hepatitis B e antigen.

Professor Ling's team concluded, "The cost-effectiveness frontiers of treatment alternatives vary and are influenced by the comparators and socioeconomic conditions of countries."

"Lamivudine-containing therapy is cost-effective when newer antiviral agents were not available."

"Economic methods should be further improved in studies, particularly in China."

J Gastroenterol Hepatol 2007: 22(9): 1369-77
04 September 2007

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