The influence of familial inflammatory bowel diseases (IBD) on phenotype and course of disease in patients with Crohn's disease and ulcerative colitis has not been studied in population-based cohorts.
Dr Magne Henriksen and colleagues from Norway assessed phenotype and course of disease between IBD patients with a first-degree relative with IBD.
The investigative team compared these with sporadic cases in a population-based cohort followed prospectively for 5 years.
Family history of IBD was registered at diagnosis and after 1 and 5 years.
|First-degree relative with IBD was registered in 15% with Crohn's disease|
|The American Journal of Gastroenterology|
Data for 200 patients with Crohn's disease and 454 with ulcerative colitis were sufficient for analysis.
The investigators found that a first-degree relative with IBD was registered in 15% of Crohn's disease patients and 10% of ulcerative colitis patients.
The team noted that the concordance for type of disease was 82% and 70% for Crohn's disease and ulcerative colitis, respectively.
No differences between familial and sporadic cases as regards localization and behavior of disease in Crohn's or disease extent in ulcerative colitis were observed.
The team noticed in Crohn's disease patients with colonic involvement, those in the familial group were significantly younger at diagnosis than the sporadic cases.
The investigators did not observe differences in disease severity in Crohn's disease patients was observed between the familial and sporadic groups.
In ulcerative colitis patients relapse was more frequent in familial cases, but no difference was observed in the need for surgery or medical treatment.
Dr Henriksen's team concluded, "A family history of IBD does not seem to influence phenotype or to be an important prognostic factor for disease course in IBD patients."