Gastric acid plays a crucial role in non-hem iron absorption.
During the long-term treatment of patients with hereditary hemochromatosis, proton pump inhibitors (PPIs) reduce the requirement for maintenance phlebotomy.
Dr Adrian Bomford and colleagues from the United Kingdom investigated if proton pump inhibitors-induced suppression of gastric acid would reduce dietary iron absorption in C282Y homozygous patients.
|PPIs administered for 7 days suppressed absorption of non-hem iron|
The team observed phlebotomy requirements to keep serum ferritin 50 µg/l before
and during administration of proton pump inhibitors in 7 patients.
The team performed a post-prandial study to determine whether proton pump inhibitors reduce absorption of non-hem iron from a test meal in a further 14 phlebotomized patients with normal iron stores.
The researchers found a significant reduction in the volume of blood removed annually before and while taking a proton pump inhibitor.
Administration of proton pump inhibitors for 7 days suppressed absorption of non-hem iron from the meal.
Dr Bomford's team concluded, "Administration of a proton pump inhibitors to patients with hereditary hemochromatosis can inhibit the absorption of non-hem iron from a test meal and the habitual diet."