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 20 February 2018

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News

Serum sodium predicts survival of patients awaiting liver transplants

Serum sodium predicts survival of patients with cirrhosis awaiting liver transplantation, shows September's issue of Gut.

News image

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Serum sodium predicts prognosis in cirrhosis and may improve the prognostic accuracy of the model for end-stage liver disease score,.

However, the available information is limited.

Dr Pere Ginès and colleagues from Spain assessed 308 patients with cirrhosis awaiting liver transplantation during a 5-year period.

The team compared the prognostic value of serum sodium in the prediction of survival at 3 and 12 months with that of the model for end-stage liver disease score.

The end-point was survival at 3 and 12 months before transplantation.

Variables obtained at the time of listing were analyzed for prognostic value using multivariable analysis.

Low serum sodium was associated with an increased risk of death
Gut

The research team evaluated the accuracy of prognostic variables by receiver operating characteristic curves.

The researchers found that the model for end-stage liver disease score and serum sodium concentration were the only independent predictors of survival at 3 and 12 months after listing.

Low serum sodium was associated with an increased risk of death in all subpopulations of patients with cirrhosis.

The patients had been categorized according to the major complication developed before listing.

The team found the area under the receiver operating characteristic curves for serum sodium and model for end-stage liver disease score was not different at 3 or 12 months.

The researchers found that the addition of serum sodium did not improve the accuracy of the model for end-stage liver disease score in the prediction of survival at 3 and 12 months.

Dr Ginès' team concluded, "In patients with cirrhosis awaiting liver transplantation, serum sodium and model for end-stage liver disease were found to be independent predictors of survival."

"Larger studies are needed to determine whether the addition of serum sodium to model for end-stage liver disease can improve its prognostic accuracy."

Gut 2007: 56(9): 1283-90
22 August 2007

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