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 20 May 2018

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News

Increased prevalence of C difficile colitis in US hospitals

This month's Archives of Surgery assesses the prevalence, severity and mortality rates of C difficile colitis over the past decade.

News image

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Clostridium difficile is a common cause of nosocomial diarrhea that has been shown to be increasing in virulence in Canada and across Europe.

Dr Nancy Baxter and colleagues from Massachusetts, USA evaluated changes in the epidemiological features of C difficile colitis in hospitalized patients in the United States.

The team of doctors performed a cohort analysis of all patients with C difficile colitis from 1993 to 2003.

The team used population-based data from the Nationwide Inpatient Sample, a 20% stratified random sample of US hospital discharge abstracts.

Total mortality rate of C difficile colitis increased
Archives of Surgery

In addition, the team applied standard International Classification of Diseases, Ninth Revision diagnostic codes to identify patients with C difficile colitis.

The team of doctors controlled for comorbid conditions by calculating the Deyo modification of the Charlson score.

To determine the relationship of year of diagnosis on main outcome measures, the team constructed multivariate models.

The main outcomes were the prevalence, case fatality, total mortality rate, and colectomy rate of C difficile colitis.

The doctors found that the prevalence, case fatality, total mortality rate, and colectomy rate of C difficile colitis increased from 1993 through 2003.

In a regression analysis, the year of diagnosis predicted an increase in prevalence, case fatality, total mortality rate, and colectomy rate after adjusting for confounders.

Dr Baxter's team comments, "The prevalence, case fatality, total mortality rate, and colectomy rate of C difficile colitis significantly increased from 1993 to 2003."

"These findings provide compelling evidence of the changing epidemiological features of C difficile colitis."

Arch Surg 2007: 142(7): 624-31
25 July 2007

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