Barrett's esophagus is a strong risk factor for esophageal adenocarcinoma, but little is known about its associations with body mass index or abdominal obesity.
Dr Douglas Corley and colleagues from California, USA conducted a case-control study within the Kaiser Permanente Northern California population.
Persons with a new diagnosis of Barrett's esophagus were matched to subjects with gastroesophageal reflux disease (GERD) without Barrett's and to population controls.
Subjects completed questionnaires and an anthropometric examination.
|There was no association between Barrett's and body mass index|
The research team interviewed 320 cases, 316 patients with GERD, and 317 controls.
There was a general association between Barrett's esophagus and a larger abdominal circumference compared with population controls.
There was a possible risk plateau, with increased risk evident only at circumferences over 80 cm, and no significant trend for further increases in circumference.
The researchers found a trend for association compared with patients with GERD.
There was no association between Barrett's esophagus and body mass index.
The team noted that abdominal circumference was associated with GERD symptom severity.
Adjustment for GERD partially attenuated the association between Barrett's esophagus and circumference.
Dr Corley's team comments, "Waist circumference, but not body mass index, had some modest independent associations with the risk of Barrett's esophagus."
"The findings provide partial support for the hypothesis that abdominal obesity contributes to GERD, which may in turn increase the risk of Barrett's esophagus."