Dr Thomas Starzl and colleagues from Pittsburgh, USA report on the progress of a man with type 1 diabetes who presented with end-stage chronic Hepatitis B virus in 1988.
In July of that year, the liver and pancreas of a cadaveric donor were transplanted separately into this patient.
|Enteric drainage of pancreatic exocrine secretions may explain the transplant success|
The research team retrospectively investigated the reasons for the patient's transplant success.
The team identified 2 features of the operation that may help explain the patient's current status as the longest-lived liver-pancreas recipient.
The researchers found that the first reason was enteric drainage of pancreatic exocrine secretions.
The other was delivery of the pancreas venous effluent to the host portal system, and then directly to the hepatic allograft.
Dr Starzl's team concludes, "We identified features that may explain the longevity of the transplants in the recipient."