Severe acute pancreatitis is a multisystem disease in which various local and systemic complications lead to high mortality.
Dr Jyrki Mäkelä and colleagues retrospectively examined the clinical and biochemical factors that may influence the risk of mortality on admission to emergency and intensive care units.
The team evaluated 68 patients admitted into hospital for acute pancreatitis.
The patients were treated for computed tomography-proven severe acute pancreatitis during the years 1997 to 2004.
|Mortality rate during the intensive care unit stay was 18%|
|American Journal of Surgery|
The clinical, biochemical, and radiologic data were reviewed from the computerized database, radiologic films, and patient records.
The researchers noted that the mortality rate during the intensive care unit stay was 18%, and that during the whole period of hospitalization was 26%.
The team found that a C-reactive protein value over 150 was the only independent predictor of mortality on admission into the emergency unit.
The computed tomography severity index and the elevated C-reactive protein value over 150 predicted mortality on admission into the intensive care unit.
Linear backward regression analysis showed that high C-reactive protein values and respiratory failure on admission correlate with longer intensive care unit stay.
The research team observed that men's intensive care unit stays were longer than those of women.
Dr Mäkelä's team concludes, "A high computed tomography severity index and C-reactive protein values over 150 on admission into the intensive care unit are valuable predictors of the mortality risk."
"High C-reactive protein, renal and respiratory failure, and male gender are associated with longer intensive care unit stay."