Risk factors for adenocarcinoma of the esophagus and gastric cardia are not yet established.
Dr de Jonge and colleagues from the Netherlands compared environmental risk factors between patients with adenocarcinoma of the esophagus and gastric cardia.
The team assessed 126 patients with adenocarcinoma of the esophagus .
Of these, 43 had adenocarcinoma of the gastric cardia, and 57 had squamous cell carcinoma.
The patients filled out a questionnaire with information on demographic and lifestyle characteristics.
|Gastric cardia vs adenocarcinoma patients had heartburn less often|
|Alimentary Pharmacology & Therapeutics|
Physical activity levels, family history, gastro-esophageal reflux disease (GERD) symptoms and medication use were also assessed.
The investigators found that adenocarcinoma of the esophagus and gastric cardia patients were similar with regard to male predominance and age.
These patients were also similar regarding alcohol intake and smoking, use of fruits and vegetables, body posture and occupational activities.
The team noted that gastric cardia patients had heartburn less often compared with adenocarcinoma of the esophagus patients.
Gastric cardia patients had these symptoms less frequently and for a shorter period.
The investigators found former and current aspirin use was lower among gastric cardia patients than adenocarcinoma of the esophagus patients.
The team detected no difference in non-steroidal anti-inflammatory drug use.
Dr de Jonge and team concluded, "Although adenocarcinoma of the esophagus and gastric cardia share several environmental risk factors, adenocarcinoma of the esophagus is more frequently associated with a history of gastro-esophageal reflux disease."
"This suggests a more important role for gastro-esophageal reflux in adenocarcinoma of the esophagus compared with gastric cardia."