Polyposis is an autosomal-dominant syndrome characterised by the development of hamartomatous gastrointestinal polyps, and is associated with colorectal cancer.
However, the relative and absolute risk of colorectal malignancy in these patients is not known.
Dr Giardiello and colleagues from Baltimore, USA compared the incidence rates of colorectal cancer in patients with polyposis with that of the general population.
The team conducted the comparison through person-year analysis with adjustment for demographics.
|The cumulative life-time risk for colorectal cancer was 39%|
The researchers found that in patients with polyposis, the relative risk of colorectal cancer was 34.
Similar risks were noted in both males and females.
The team noted that the cumulative life-time risk for colorectal cancer was 39%.
The mean age of diagnosis of colorectal cancer was 44 years.
The research team did not observe other gastrointestinal malignancies in this cohort.
Dr Giardiello and team conclude, "Patients with polyposis have a markedly increased relative and absolute risk for colorectal cancer, and require vigilant colorectal surveillance starting at young age."
"A low threshold for recommending surgery with consideration for removal of the entire colorectum seems warranted."