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 19 February 2018

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News

The role of laparoscopy and radical resection in gallbladder cancer

June's issue of the Annals of Surgery assesses whether radical resection in patients with gallbladder cancer is beneficial

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The widespread adoption of laparoscopic cholecystectomy has led to an increased frequency of incidentally discovered gallbladder carcinoma.

Little data exist to guide surgeons in the optimum management of patients with gallbladder cancer, particularly with respect to the potential advantages of radical resection.

Dr Samuel Shih and colleagues assessed how laparoscopy has altered the presentation of patients with gallbladder cancer to determine whether radical resection in patients with gallbladder cancer is beneficial.

The median age at presentation was 67 years and 66% were female
Annals of Surgery

Records of 107 patients with gallbladder cancer admitted to a tertiary academic medical center between 1995 and 2004 were reviewed.

Gallbladder cancer was found incidentally in 53 patients (50%).

52 of these patients underwent a routine laparoscopic cholecystectomy and were found to have gallbladder cancer intraoperatively or following the operation by subsequent pathologic evaluation of the specimen.

Gallbladder cancer had been diagnosed pre-operatively by radiology in the other 54 patients (50%).

These patients did not undergo laparoscopic cholecystectomy and were explored electively.

The median age at presentation was 67 years and 66% were female.

Patients who were found to have gallbladder carcinoma incidentally at laparoscopic cholecystectomy had a significant increase in survival when compared with those who were admitted electively with a known diagnosis (P < 0.001).

All patients who presented with a known diagnosis had stage II or greater disease, and 36% of these were stage IV carcinomas, however, 82% of those patients who were found incidentally were stage I or II.

The overall 5-year survival for all patients was 15%; those discovered incidentally at laparoscopic cholecystectomy had a 5-year survival of 33%.

This difference was significant among patients with stage II carcinomas.

In the laparoscopic group, there was no difference in survival between the patients who were immediately converted to an open resection when identified to have gallbladder cancer intra-operatively (n = 6) and those who had a completed laparoscopic cholecystectomy and were re-explored at a later point when found to have gallbladder cancer by subsequent pathology (n = 33).

There was a significant improvement in survival in 50 patients (47%) who underwent some form of radical resection (P < 0.001).

Stage-for-stage comparison showed that this was significant in stage II disease.

Patients who underwent hepatic resection along with lymphadenectomy and extra hepatic biliary resection had similar survival compared with those who had hepatic resection and lymphadenectomy alone.

Dr Shih concluded that, "Laparoscopic cholecystectomy appears to have resulted in the earlier discovery of gallbladder cancer in some patients, resulting in increased probability of survival."

Also, "Patients discovered with gallbladder carcinoma during a laparoscopic cholecystectomy do not have to be converted immediately to an open resection and should be referred to a tertiary care center for further exploration. Adjunctive radical surgical resection, either at the time of cholecystectomy or subsequently, increases survival significantly in early stages of disease".

Annals of Surgery 2007; 245 (6), 893-901
14 June 2007

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