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News

Gastric bypass in obesity reduces Framingham risk of cardiac events

The risk of cardiovascular events in obesity is reduced by gastric bypass operations, shows this month's issue of the Journal of American College of Surgery

News image

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Obesity is known to be a major risk factor for cardiovascular diseases.

There are few studies in the literature assessing the effect of bariatric procedures on longterm risk of cardiovascular events.

Dr Alfonso Torquati and colleagues from Tennessee determined the effect of gastric bypass operation on actual and Framingham risk of coronary heart disease events in obesity.

The team used the observed change in coronary heart disease risk factors to calculate the predicted 10-year risk of coronary heart disease after gastric bypass operations.

In addition, the research team used risk models derived from the Framingham data equation to calculate the predicted 10-year risk.

The risk predicted by the Framingham model was then compared with the actual incidence of coronary heart disease events of the cohort.

Gastric bypass decreased absolute risk of cardiac events by 56% in men
Journal of American College of Surgeons

The researchers evaluated 500 patients.

The 1-year mean excess body weight loss was 69%.

The research team found a substantial reduction in prevalence of diabetes from 28% to 6% after the operation.

The team found compared with baseline, the average 10-year absolute risk of cardiac events decreased from 5% at baseline to 3% at 1 year after operation.

The researchers observed a similar risk reduction in subgroups defined by diabetes status and gender.

Gastric bypass decreased absolute risk of cardiac events by a mean of 63% in diabetics and 56% in male patients.

The cohort actual rate of coronary heart disease events was 1%.

At the 5-year horizon, the team noted that the rate of coronary heart disease events was lower than the predicted rate before gastric bypass operation.

Dr Torquati's team concluded, "Gastric bypass operation is effective in reducing actual and the 10-year Framingham risk of coronary heart disease events in individuals with class II to III obesity."

"The major estimated risk reduction was observed in male patients with type 2 diabetes."

J Am Coll Surg 2007: 204(5): 776-82
23 May 2007

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