Hepatitis virus coinfections may progress more rapidly to cirrhosis than Hepatitis B or C monoinfections in immunocompetent patients.
Only limited information is available on the outcome of coinfected patients after liver transplantation.
Professor Hans Tillmann and colleagues from Germany studied survival rates of 204 patients with viral Hepatitis transplanted between 1972 and 1997.
The team found that Hepatitis B/Hepatitis D and Hepatitis B/Hepatitis C coinfections were present in 23 and 9 individuals, respectively.
The researchers noted that 97 patients had monoinfection by Hepatitis C and 75 had Hepatitis B monoinfection.
The research team found that survival of coinfected patients was significantly longer than that of monoinfected patients.
|Viral coinfections may ameliorate courses of diseases|
The team observed that the same was true for graft survival.
In Cox's regression, viral coinfection, absence of hepatocellular carcinoma, and no retransplantation were independently associated with patient survival.
The researchers conducted further analysis after excluding 62 patients with hepatocellular carcinoma.
The research team noted that survival of coinfected patients was still significantly longer than that of monoinfected individuals.
The improved outcome was similar for both Hepatitis B/Hepatitis D and Hepatitis B/Hepatitis C coinfections.
Professor Tillmann's team commented, “In contrast to immuno-competent patients, individuals with multiple Hepatitis virus infections had an improved outcome after liver transplantation.”
“Viral coinfections may be associated with ameliorated courses of diseases under certain conditions.”