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 21 February 2018

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News

Pulmonary disease mortality is increased in ulcerative colitis

Researchers find a significant rise in standardized mortality ratios for pulmonary disease in patients with ulcerative colitis, reported in the latest issue of Gut.

News image

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Population-based studies have revealed varying mortality for patients with ulcerative colitis.

However, most have described patients from limited geographical areas who were diagnosed before 1990.

Dr Höie and colleagues from Norway assessed overall mortality in a European cohort of patients with ulcerative colitis, and 10 years after diagnosis.

The standardized mortality ratio for overall mortality was 1.1
Gut

The team recorded ulcerative colitis mortality 10 years after diagnosis was recorded in a prospective European-wide population.

The patients were diagnosed from 1991 to 1993 from 9 centers in 7 European countries.

Expected mortality was calculated from the sex, age and country specific mortality in the World Health Organisation Mortality Database for 1995 to 1998.

The research team calculated standardized mortality ratios, and 95% confidence intervals.

The researchers found that 661 of 775 patients were alive with a median follow-up duration of 123 months.

A total of 73 deaths occurred compared with an expected 67.

The team observed that overall mortality risk was no higher, with a standardized mortality ratio of about 1.1

Mortality by sex showed a standardized mortality ratio of 0.9 for males and 1.4 for females.

The research team noted that there was a slightly higher risk in older age groups.

For disease specific mortality, a higher standardized mortality ratios was found only for pulmonary disease.

The team found that the standardized mortality ratios by European region were 1.2 for the north, and 0.8 for the south.

Dr Höie's team concluded, “Higher mortality was not found in patients with ulcerative colitis 10 years after disease onset.”

“However, a significant rise in standardized mortality ratios for pulmonary disease, and a trend towards an age related rise in standardized mortality ratios, was observed.”

Gut 2007: 56(4): 497-503
21 March 2007

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