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 18 October 2017

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GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

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RoyPounder

Favorite slide

Crohn's Disease is a Granulomatous Vasculitis

This slide is the bowel wall of a patient with Crohn's disease. It shows one blood vessel going up the screen, and another blood vessel at right angles. This demonstrates that Crohn's disease is a granulomatous vasculitis - notice the two granulomata in otherwise normal blood vessels (Wakefield et al., Gastroenterology 1991; 100: 1279-87). Research at the Royal Free has shown that measles virus can be found in the heart of these granulomata. This is the basis for our hypothesis that Crohn's disease is a granulomatous vasculitis due to a persisting infection with measles virus, in genetically-susceptible individuals.

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