The appearance of squamous cell epithelium in the cardia and fundus
This slide demonstrates the appearance of squamous cell epithelium in the cardia and fundus of a patient, who underwent reversal of Barrett's esophagus by multipolar electrocoagulation. Inadvertent thermal-induced injury to the proximal stomach in patients receiving high-dose proton pump inhibitors resulted in healing by squamous, rather than columnar, epithelium.
This is the first documentation of squamous cell epithelium appearing de novo within the proximal portion of the stomach.
It is speculated that stem cells lining the esophagus and the gastric cardia are pluripotent, differentiating into columnar cells in an acidic environment or squamous cells in an acid-suppressed environment.
Download the slide