Researchers from New York and Minnesota, USA, assessed the effect on treatment outcome of coinfection with SEN viruses in patients with chronic hepatitis C.
The newly discovered SEN D and SEN H viruses are transmitted parenterally and can cause post-transfusion hepatitis.
Thus, the team wanted to find out if these viruses interfered with interferon and ribavirin therapy.
Of 31 patients with hepatitis C studied, 6 were found to be positive for SEN D and 7 for SEN H (1 was positive for both).
| Overall response to interferon and ribavirin was lower in SEN-infected patients.
All of those who were positive for SEN D and 5 of those who were positive for SEN H failed to respond to therapy.
The team found that overall response (RNA titer and alanine aminotransferase concentration after treatment) was lower in SEN-infected patients than uninfected patients.
Professor Basil Rigas, of the New York Medical College, in Valhalla, concluded on behalf of his group, "Coinfection with SEN viruses is frequent in chronic hepatitis C patients and might adversely affect the outcome of treatment with interferon and ribavirin."