A team from Ankara, Turkey, determined the link between Helicobacter pylori infection and squamous cell carcinoma of the larynx (SCCL).
H. pylori is known to cause chronic infection that has been linked to the development of both benign and malignant disease of the aerodigestive tract.
A total of 26 patients with SCCL and 32 matched controls without carcinoma of the larynx were enrolled in the study.
|Proportion of individuals with H. pylori:|
| Otolaryngology - Head and Neck Surgery |
The presence of IgG antibodies against H. pylori antigens were estimated by using ELISA technique in the sera of each subject.
The researchers found that the incidence of seropositivity of patients with SCCL was 73% and of controls was 41%.
Dr Erdinc Aygenc, of the Ankara Numune Hospital, said on behalf of colleagues, "These data support an etiologic role for H. pylori infection on development of SCCL."
"H. pylori infection of the upper aerodigestive tract might result in mucosal disruption, allowing for subsequent transformation by known carcinogens such as tobacco and alcohol," it was concluded.