Researchers from Jacksonville, Florida, USA, examined the esophageal motility of patients with esophageal adenocarcinoma or Barrett's esophagus with high-grade dysplasia. This was done both before and after photodynamic therapy.
The study was conducted between January 1998 and October 1999.
Esophageal motility testing of the lower esophageal sphincter and esophageal body was performed with a water-perfused catheter. This was conducted 2 days before and at least 3 weeks after patients underwent photodynamic therapy for their condition.
Results were classified as normal motility, ineffective esophageal motility, or aperistalsis.
A total of 23 patients were studied, 13 with carcinoma and 10 with Barrett's esophagus.
|Normal esophageal motility in patients:|
Before photodynamic therapy: 48%
| Mayo Clinic Proceedings |
Overall, 11 patients (48%) had normal motility, 6 (26%) had ineffective esophageal motility, and 6 (26%) had aperistalsis.
Of the patients with aperistalsis, 5 had carcinoma.
Follow-up tracings after photodynamic therapy found that 6 patients (26%) had normal motility, 7 (30%) had ineffective esophageal motility, and 10 (43%) had aperistalsis.
Author N. Malhi-Chowla, of the Mayo Clinic, Jacksonville, said on behalf of the group, "Esophageal dysmotility is common in patients with esophageal adenocarcinoma or Barrett's esophagus.
"Photodynamic therapy may worsen esophageal motility in some patients."
"Dysphagia after photodynamic therapy therefore may be related to underlying esophageal dysmotility and may not always be caused by stricture or underlying carcinoma," it was concluded.