The researchers assessed the long-term risk of colorectal cancer following screening endoscopy. This was done in a statewide population-based study in Saarland, Germany.
Lifetime history of screening endoscopy was compared between 320 cases with colorectal cancer, aged 45-80, and 263 controls with other forms of cancer, recruited from the same population.
Potential confounding factors were controlled for by multiple logistic regression.
| Screening endoscopy reduces long-term risk of colorectal cancer by 60%.
| British Journal of Cancer |
The team found that 11% of cases, compared to 27% of controls, had a history of endoscopy for screening purposes (adjusted odds ratio [OR] = 0.28).
This strong risk reduction was also seen (OR = 0.41) in subjects who had their last screening endoscopy more than 10 years ago (median: 19 years).
Long-term (greater than 10 years since last screening) risk reduction appeared to be particularly strong for advanced (Dukes C or D) colorectal cancer. The adjusted odds ratio was 0.19.
Author H. Brenner concluded on behalf of fellow colleagues, "Risk reduction by screening endoscopy is long lasting, in particular with respect to advanced colorectal cancer."